Nortilidine is an opioid drug, in the form of a solution, the main metabolite of tilidine, or rather it is formed from tilidine, by demethylation in the liver. The (1S,2R) isomer is an NMDA antagonist and acts as a dopamine reuptake inhibitor. It has excellent analgesic properties, equivalent in potency to morphine, opioid effects are similar to morphine. This drug is actively used in the treatment of pain in the EU countries.
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Description
(1R,2S)-nortilidine is an ethyl 2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate that is ent-dextilidine in which one of the methyl groups attached to the nitrogen is replaced by hydrogen. ent-Dextilidine is metabolised to (1R,2S)-nortilidine by the liver. It has a role as a drug metabolite and a NMDA receptor antagonist. It is an enantiomer of a (1S,2R)-nortilidine.
4-ANPP or N-phenyl-1- (2-phenylethyl) -4-piperidinamine is a new designer drug, classified as piperidinamine. This chemical is synthesized as an intermediate between fentanyl from N-phenethyl-4-piperidone. 4-ANPP impurity which is presncndetn in fentanyl preparations. 4-ANPP is a metabolite of acetylfentanyl, butyrylfentanyl and furanylfentanyl. 4-ANPP produced in modern chemical laboratory, professionals who know their business, which makes it the highest quality.
2-methyl-ap-237 is a new research chemical, classifying the analgesic opioid. 2-methyl-ap-237 is used in Southeast Asia as a powerful analgesic, with a variety of disorders. It has legal status in many countries. 2-methyl-ap-237 is very similar in action to morphine but is several times superior in potency, unlike morphine, they are strong and selective agonists of the μ-opioid receptor-MOR with a relatively low affinity for the δ-opioid receptor and κ-opioid receptor.
Dipyanone is an opioid analgesic, homologous to dipipanone and has a similar effect. Dipyanone might be a potent agonist at the μ-opioid receptor and is essentially an alternative to morphine.
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