5-MeO-TMT or 5-Methoxy-2, N, N-trimethyltryptamine (5-MeO-2, N, N-TMT, 5-MeO-TMT) designer drug tryptamine with a psychoactive psychedelic effect. 5-MeO-TMT synthesized by Alexander Shulgin. 5-MeO-TMT acts in chemical studies as follows: a methyl group in position, two molecules disrupt the binding of metabolic enzymes such as monoamine oxidase, it also inhibits the binding and activation of the 5-HT2A serotonin receptor, which causes hallucinating effects like most psychedelic drugs.

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5-Methoxy-2,N,N-trimethyltryptamine (5-MeO-2,N,N-TMT, 5-MeO-TMT) is a psychoactive drug of the tryptamine chemical class which acts as a psychedelic. It was first synthesized by Alexander Shulgin and reported in his book TiHKAL (“Tryptamines i Have Known And Loved”). It is claimed to show psychoactive effects at a dosage of 75-150 mg orally, but these are relatively mild compared to those of other similar compounds. This suggests that while the methyl group on the 2-position of the molecule has impaired the binding of metabolic enzymes like monoamine oxidase (MAO), it is also interfering with binding to and/or activation of the serotonin 5-HT2A receptor, the target responsible for mediating the hallucinogenic effects of such compounds.

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